Based on our computer model, the Buffalo Bills will defeat the Jacksonville Jaguars when they square off at Highmark Stadium on Monday, Sept. 23 (at 7:30 p.m. ET). We have more projections, regarding the point spread, total and final score, available in this article.

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The Bills are totaling 299.5 yards per game on offense, which ranks them 19th in the NFL. On the other side of the ball, they rank 13th, surrendering 310.5 yards per contest. The Jaguars’ offense has been a bottom-five unit this season, compiling 15 points per game, which ranks fourth-worst in the NFL. Defensively, they rank ninth with 19 points allowed per contest.

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Jaguars vs. Bills Predictions and Picks

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Jaguars Betting Info

• The Jaguars have a 33.3% chance to win this game based on the implied probability of the moneyline.
• Jacksonville has covered once in two chances against the spread this year.
• Jacksonville has yet to hit the over in any game this year.
• Games involving the Jaguars this year have averaged 45.3 points per game, a 0.2-point differential when compared to the over/under for this contest.

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Bills Betting Info

• The Bills have a 71.4% chance to win this matchup based on the moneyline’s implied probability.
• Buffalo has a record of 1-1-0 against the spread this season.
• The Bills have not covered the spread when favored by 5.5 points or more this season (in one opportunity).
• Games featuring Buffalo have hit the over once this season.
• Bills games have had an average of 47.3 points this season, 1.8 points higher than the over/under for this matchup.

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Jaguars vs. Bills 2024 Scoring Insights

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